Morphomics is amazingly predictive beyond just surgical procedures; it can predict tumor recurrence and outcomes better than surgical staging for numerous cancers, as well as treatment response for many diseases.
Here is a sample of the ever growing body of published research using Morphomics:
Measuring Rib Cortical Bone Thickness and Cross Section from CT. Holcombe SA, Hwang E, Derstine BA, Wang SC Med Image Anal. 2018 Jul 10;49:27-34. doi: 10.1016/j.media.2018.07.003.
Validation of a DIXON-Based Fat Quantification Technique for the Measurement of Visceral Fat Using a CT-Based Reference standard. Heckman KM, Otemuyiwa B, Chenevert TL, Malyarenko D, Derstine BA, Wang SC, Davenport MS Abdom Radiol (NY). 2018 Jun 27. doi: 10.1007/s00261-018-1678-x. [Epub ahead of print] PubMed PMID: 29946923.
Measurement of Skeletal Muscle Area Improves Estimation of Aminoglycoside Clearance across Body Size. Crass RL, Ross BE, Derstine BA, Lichty M, Sullivan JA, Su GL, Wang SC, Pai MP. Anitmicrob Agents Chemother. 2018 May;62(6). pii: e00441-18 doi: 10.1128/AAC.00441-18. Print 2018 Jun. PubMed PMID: 296320217; PubMed Central PMCID: PMC5971580.
Morphomic Malnutrition Score: A Standardized Screening Tool for Severe Malnutrition in Adults. Lee C, Raymond E, Derstine BA, Glazer JM, Goulson R, Rajasekaran A, Cherry Bukowiec J, Su GL, Wang SC. JPEN J Parenter Enteral Nutr. 2018 May 22. doi: 10.1002/jpen.1175. [Epub ahead of print] PubMed PMID: 29786877.
Patient Engagement Drives the Positive Impact of Prehabilitation. Owen H. Brown, BS; Brooke C. Kenney, MPH; Brian A. Derstine, MS; Dane R. Grenda, DO; June A. Sullivan, MBA; William C. Palazzolo, PA-C; Stewart C. Wang, MD, PhD; Michael J. Englesbe, MD MJM Michigan Journal of Medicine 2018 April. DOI: 10.3998/mjm.13761231.0003.106.
Evaluating the "Cushion Effect" Among Children in Frontal Motor Vehicle Crashes. Harbaugh CM, Zhang P, Henderson B, Derstine BA, Holcombe SA, Wang SC, Kohoyda-Inglis C, Ehrlich PF. J Pediatr Surg. 2018 Feb 10. pii: S0022-3468(18)30096-4. doi: 10.1016/j.jpedsurg.2018.02.042. [Epub ahead of print] PubMed PMID: 29519566.
Analytic Morphomics Predict Outcomes After Lung Transplantation. Pienta MJ, Zhang P, Derstine BA, Enchakalody B, Weir WB, Grenda T, Goulson R, Reddy RM, Chang AC, Wang SC, Lin J. Ann Thorac Surg. 2018 Feb;105(2):399-405. doi: 10.1016/j.athoracsur.2017.08.049. Epub 2017 Dec 2. PubMed PMID: 29198627; PubMed Central PMCID: PMC5783736.
Quantifying Sarcopenia Reference Values Using Lumbar and Thoracic Muscle Areas in a Healthy Population. Derstine BA, Holcombe SA, Goulson RL, Ross BE, Wang NC, Sullivan JA, Su GL, Wang SC. J Nutr Health Aging. 2017;21(10):180-185. doi: 10.1007/s12603-017-0983-3.
Relationships of Vancomycin Pharmacokinetics to Body Size and Composition Using a Novel Pharmacomorphomic Approach Based on Medical Imaging. Pai MP, Derstine BA, Lichty M, Ross BE, Sullivan JA, Su GL, Wang SC. Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01402-17. doi: 10.1128/AAC.01402-17. Print 2017 Nov. PubMed PMID: 28807918; PubMed Central PMCID: PMC5655058.
The 'Cushion Effect' Is Not Protective for Children Involved in Motor Vehicle Crashes. Calista Harbaugh, MD, Brianna Henderson, Peng Zhang, PhD, Brian Derstine, Sven A. Holcombe, PhD, Stewart Wang, MD, PhD, Peter F. Ehrlich, MD, FACS Journal of the American College of Surgeons, October 2017. Volume 225, Issue 4, e187 - e188
Morphometric Age and Survival Following Kidney Transplantation. Terjimanian MN, Underwood PW, Cron DC, Augustine JJ, Noon KA, Cote DR, Wang SC, Englesbe MJ, Woodside KJ. Clin Transplant. 2017 Oct;31(10). doi: 10.1111/ctr.13066. Epub 2017 Aug 28. Erratum in: Clin Transplant. 2017 Dec 16;:. PubMed PMID: 28758236.
Using Analytic Morphomics to Describe Body Composition Associated with Post-Kidney Transplantation Diabetes Mellitus. Cron DC, Noon KA, Cote DR, Terjimanian MN, Augustine JJ, Wang SC, Englesbe MJ, Woodside KJ. Clin Transplant. 2017 Sep;31(9). doi: 10.1111/ctr.13040. Epub 2017 Jul 20. PubMed PMID: 28640481.
The Effect of Age and Demographics on Rib Shape. Holcombe SA, Wang SC, Grotberg JB J Anat. 2017 Aug;231(2):229-247. doi: 10.1111/joa.12632. Epub 2017 Jun 13. PubMed PMID: 28612467.
Body Composition Predicts Survival in Patients with Hepatocellular Carcinoma Treated with Transarterial Chemoembolization. Parikh ND, Zhang P, Singal AG, Derstine BA, Krishnamurthy V, Barman P, Waljee AK, Su GL Cancer Res Treat. 2018 Apr;50(2):530-537. doi: 10.4143/crt.2017.156. Epub 2017 Jun 1.
Can Comprehensive Imaging Analysis with Analytic Morphomics and Geriatric Assessment Predict Serious Complications in Patients Undergoing Pancreatic Surgery? Benjamin AJ, Buschmann MM, Schneider A, Derstine BA, Friedman JF, Wang SC, Dale W, Roggin KK J Gastrointest Surg. 2017 Jun;21(6):1009-1016. doi: 10.1007/s11605-017-3392-3. Epub 2017 Mar 24. PubMed PMID: 28342121.
Taking Control of Your Surgery: The Impact of a Prehabilitation Program on Major Abdominal Surgery Y.S. Yin, L. McCandless, S. Wang, M. Englesbe, D. Machado-Aranda University of Michigan, Surgery, Ann Arbor, MI, USA Academic Surgical Congress. 2017.
The Michigan Surgical Home and Optimization Program is a Scalable Model to Improve Care and Reduce Costs. Englesbe MJ, Grenda DR, Sullivan JA, Derstine BA, Kenney BN, Sheetz KH, Palazzolo WC, Wang NC, Goulson RL, Lee JS, Wang SC. Surgery. 2017 Feb 4. pii: S0039-6060(16)30880-7. doi: 10.1016/j.surg.2016.12.021. [Epub ahead of print]
Personalized Medicine: Enhancing our Understanding of Pediatric Growth with Analytic Morphomics. Harbaugh CM, Zhang P, Henderson B, Derstine BA, Holcombe SA, Wang SC, Kohoyda-Inglis C, Ehrlich PF. J Pediatr Surg. 2017 Jan 29. pii: S0022-3468(17)30063-5. doi: 10.1016/j.jpedsurg.2017.01.030. [Epub ahead of print]
Reference Analytic Morphomics Population (RAMP): A Reference to Measure Occupant Variability for Crash Injury Analysis. Wang SC, Holcombe SA, Derstine BA, Goulson RL, Grenda DR, Ruan J, Rabban P, Wang NC, Friedman JF, Cron DC, Henderson BC, Sullivan JA, Kohoyda-Inglis C, Su GL, Ejima S, Zhang P. International Research Council on Biomechanics of Injury. 2016 Sep. Session S2-4 - Accident Analysis/Vehicle Technology: IRC-16-80.
Bone Mineral Density Predicts Post-Transplant Survival Among Hepatocellular Carcinoma Liver Transplant Recipient. Sharma P, Parikh ND, Yu J, Barman P, Derstine BA, Sonnenday CJ, Wang SC, Su GL Liver Transpl. 2016 Aug;22(8):1092-8. doi: 10.1002/lt.24458. Epub 2016 Jun 29.
Body Composition Features Predict Overall Survival in Patients With Hepatocellular Carcinoma. Singal AG, Zhang P, Waljee AK, Ananthakrishnan L, Parikh ND, Sharma P, Barman P, Krishnamurthy V, Wang L, Wang SC, Su GL Clin Transl Gastroenterol. 2016 May 26;7:e172. doi: 10.1038/ctg.2016.31.
Using Analytic Morphomics to Understand Short-Term Convalescence after Radical Cystectomy. Luckenbaugh AN, Hollenbeck BK, Montgomery JS, Lee CT, Gilbert SM, Dunn RL, Friedman JF, Englesbe MJ, Wang SC, Hollingsworth JM Bladder Cancer. 2016 Apr 27;2(2):235-240.
Investigating the Clinical Significance of Body Composition Changes in Patients Undergoing Chemoradiation for Oropharyngeal Cancer using Analytic Morphomics. Wang C, Vainshtein JM, Veksler M, Rabban PE, Sullivan JA, Wang SC, Eisbruch A, Jolly S. Springerplus. 2016 Apr 11;5:429. doi: 10.1186/s40064-016-2076-x. eCollection 2016.
Analytic Morphomics: A Novel CT Imaging Approach to Quantify Adipose Tissue and Muscle Composition in Allogeneic Hematopoietic Cell Translation. Chughtai K, Song Y, Zhang P, Derstine B, Gatza E, Friedman J, Hully L, Inglis C, Goldstein S, Magenau J, Pawarode A, Reddy P, Riwes M, Yank G, Wang SC, Choi SW Bone Marrow Transplant. 2016 Mar;51(3):446-50. doi: 10.1038/bmt.2015.267. Epub 2015 Nov 9.
Abdominal Adiposity, Body Composition and Survival After Liver Transplantation. Terjimanian MN, Harbaugh CM, Hussain A, Olugbade KO Jr, Waits SA, Wang SC, Sonnenday CJ, Englesbe MJ Clin Transplant. 2016 Mar;30(3):289-94. doi: 10.1111/ctr.12688. Epub 2016 Feb 13.
Sarcopenia and Failure to Rescue Following Liver Transplantation. Underwood PW, Cron DC, Terjimanian MN, Wang SC, Englesbe MJ, Waits SA Clin Transplant. 2015 Dec;29(12):1076-80. doi: 10.1111/ctr.12629. Epub 2015 Oct 15.
Morphomics Predicts Response to Ipilimumab in Patients with Stage IV Melanoma. Sabel MS, Lee J, Wang A, Lao C, Holcombe S; and Wang SC J Surg Oncol. 2015 Sep;112(4):333-7. doi: 10.1002/jso.24003. Epub 2015 Aug 7.
A Computed Tomography Study of Gender Differences in Acetabular Version and Morphology: Implications for Femoroacetabular Impingement. Tannenbaum EP, Zhang P, Maratt JD, Gombera MM, Holcombe SA, Wang SC, Bedi A, Goulet JA. Arthroscopy. 2015 Jul;31(7):1247-54. doi: 10.1016/ j.arthro.2015.02.007. Epub 2015 May 13.
Sarcopenia is Associated with Autologous Transplant-Related Outcomes in Patients with Lymphoma. Caram MV, Bellile EL, Englesbe M, Terjimanian M, Wang SC, Griggs JJ, Couriel D. Leuk Lymphoma. 2015;56(10):2855-62. doi: 10.3109/10428194.2015.1014359. Epub 2015 Jun 18.
Body Fat Composition Assessment Using Analytic Morphomics Predicts Infectious Complications after Bowel Resection in Crohn's Disease. Stidham RW, Waljee AK, Day NM, Bergmans CL, Zahn KM, Higgins PD, Wang SC, Su GL Inflamm Bowel Dis. 2015 Jun;21(6):1306-13. doi: 10.1097/MIB.0000000000000360.